TheTOPICstudy.com            
MS Clinical Research Study

• Understanding My Symptoms
• What is Multiple Sclerosis?
• What is "Possible MS"?
• What are Some Signs of MS?
• Learn More about the TOPIC Study
• Why Consider a Clinical Trial?
• Study Centers Enrolling Patients in the TOPIC Study
• Resources

You have had unexplained symptoms. Your doctor says it could be one of a number of things. One possibility is Multiple Sclerosis (MS). You probably have many questions and concerns. Now, more than ever, it is important for you to learn more.

What is Multiple Sclerosis? top

Every nerve in your body is covered by a substance called myelin (my-eh-lin). Myelin helps to protect your nerves and carries signals to every part of your body. In MS, this myelin covering becomes swollen and damaged. The result is scarring, or sclerosis (skle-ro-sis). This nerve scarring can slow or prevent the delivery of nerve messages, affecting muscle coordination, strength, sensation, and vision.

What is Possible MS? top

Most people who have been diagnosed with MS have a period of uncertainty after the first appearance of symptoms. The symptom(s) you are experiencing may suggest a diagnosis of Multiple Sclerosis, but this diagnosis has not yet been confirmed. It can be very difficult to wait until a second episode occurs before seeking a firm diagnosis and exploring treatment options.

This information is not intended as medical advice. Please consult your physician for medical information regarding your condition and whether or not you may have MS.

What are Some Signs of Multiple Sclerosis? top

Everyone experiences symptoms a little differently. However, some common signs of MS include:

• Double vision or blurring of vision
• Tingling or pain in parts of your body
• Electric-shock sensations with certain head movements
• Tremors, lack of coordination or balance
• Extreme lack of energy
• Dizziness
• Numbness or weakness in arms or legs

Learn More About the TOPIC study. top

The TOPIC study is testing an oral investigational medication versus placebo for those at high risk of developing MS. Medical research has shown that such people may benefit by being treated with medication earlier rather than waiting for a definitive diagnosis of MS.

To learn more about the TOPIC study and this potential oral therapy, please download the TOPIC study brochure to learn more about this important clinical research study.

Why Consider a Clinical Trial? top

The injection and infusion medications currently approved for the treatment of MS were developed through the clinical research process. This process allows researchers to gather valuable information on the safety and effectiveness of investigational medications. By participating in a clinical trial, you will receive:

• Ongoing study-related monitoring by a team of medical professionals
• Extensive screening tests including ongoing MRI exams
• All study-related visits and tests provided at no cost.

Study Centers Enrolling Patients
in the TOPIC Study: top

Below is a list of study centers that are currently enrolling patients. Please contact the study center nearest you to see if you qualify for the TOPIC study.

Active US Sites

• MS Clinic of Central Texas, Central Texas Neurology Consultants
  (512) 218-1222
  Round Rock, TX 78681
• Neurology Specialists, Inc.
  (937) 495-0000x142
  Dayton, OH 45417
• Fort Wayne Neurological Center
  (260) 436-3991x2143
  Fort Wayne, IN 46804
• Neurology Associates, P.A.
  (407) 647-5996x204
  Maitland, FL 32751
• LSUHSC Dept of Neurology
  (318) 813-1453
  Shreveport, LA 71103
• George Washington University, Dept of Neurology
  (202) 741-2717
  Washington, DC 20037
• Mount Sinai School of Medicine; Corinne Goldsmith Dickinson Center for MS
  (212) 241-7858
  New York, NY 10029
• University of Kentucky Medical Center
  (859) 218-5006
  Lexington, KY 40536
• MidAmerica Neuroscience Institute
  (913) 894-1500x151
  Lenexa, KS 66214
• Fletcher Allen Health Care, Dept of Neurology
  (802) 656-9915
  Burlington, VT 05405
• Saint Louis University, Dept of Neurology
  (314) 977-4867
  St. Louis, MO 63104
• SUNY Stony Brook Dept of Neurology
  (631) 444-3448
  Stony Brook, NY 11794
• Kelsey-Seybold Clinic
  (713) 442-1224
  Houston, TX 77025
• Josephson Wallack Munshower Neurology, PC
  (317) 537-6060
  Indianapolis, IN 46256
• The Neurological Institute, P.A.
  (704) 331-7856
  Charlotte, NC 28204
• NeuroTrials Research, Inc.
  (404) 851-9934
  Atlanta, GA 30342
• Xenoscience
  (602) 274-9500
  Phoenix, AZ 85004
• MS Specialty Clinic UNM
  (505) 272-0356
  Albuquerque, NM 87131
• Northern Michigan Neurology
  (231) 935-0340
  Traverse City, MI 49684
• Suncoast Neuroscience Associates, Inc.
  (727) 824-7135
  St. Petersburg, FL 33701
• St. Mary's Healthcare
  616-752-5435
  Grand Rapids, MI 49503
• Albert Einstein Medical Center, Neurosensory Sciences
  
  Philadelphia, PA 19141
• Baptist Neurology Center
  (859) 260-4388
  Lexington, KY 40503
• Regional MS Center at Regional MS Center at St. Lukes Medical Center
  (414) 649- 5097
  Milwaukee, WI 53215
• University of California, Irvine
  (949) 824-7524
  Irvine, CA 92697

Coming Soon (US)

Resources

To learn more about MS, visit the links below:

Accelerated Cure Project for MS

www.acceleratedcure.org

Dedicated to curing MS by determining the cause of MS.

National MS Society

www.nationalmssociety.org

Committed to helping each person address the challenges of living with MS through a 50 state network of chapters.

The Huega Center for MS

www.heuga.org

Offers comprehensive programs that empower people and families living with MS to transform and improve their quality of life.

Multiple Sclerosis International Federation

www.msif.org

Dedicated to leading the global MS movement by stimulating research into the understanding and treatment of MS.